by SPRINGER-VERLAG .
Written in English
|The Physical Object|
|Number of Pages||169|
The biological importance of 5-mC as a major epigenetic modification in phenotype and gene expression has been widely recognized. For example DNA hypomethylation, the decrease in global DNA methylation, is likely caused by methyl-deficiency due to a variety of environmental influences and has been proposed as a molecular marker in multiple biological processes . Alterations of DNA methylation in cancer cells can be classified into two types, namely regional hypermethylation (aberrant DNA methylation of CpG island) and global hypomethylation ().Regional hypermethylation (aberrant DNA methylation) represents increased DNA methylation of CpG islands unmethylated in normal cells, and aberrant DNA methylation of promoter CpG Cited by: 2. Methylation plays an interesting and important role in cancer development. Cancer develops largely as a result of an undoing of normal gene expression. Instead of healthy development and aging governed by patterned and controlled gene regulation, cancer is birthed from unbalanced and chaotic gene expression. DNA methylation is one of the epigenetic mechanisms that is closely associated with normal cell development and a number of key processes including imprinting, X-chromosome inactivation, repression of repetitive element transcription, chromatin organization, etc. [7–9].Aberrant methylation patterns are known to be presented in the genomes of cancer : Le Huyen Ai Thuy, Lao Duc Thuan, Truong Kim Phuong.
Changes in DNA methylation in cancer have been heralded as promising targets for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite the existence of more than Cited by: DNA Methylation, Epigenetics and Metastasis It seems that you're in USA. We have a dedicated site for USA Get immediate ebook access* when you order a print book Biomedical Sciences Cancer Research. Mechanisms of DNA Demethylating Drugs Against Cancer Progression. Pages Dai, Zunyan (et al.). DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat terns emerged as the only component of the chemical structure.
This book is a comprehensive survey of new and exciting developments regarding the role of DNA methylation in human cancer. Issues related to the mutagenicity of 5-methylcytosine and the increase in the interaction of chemical and physical carcinogens with these residues is discussed. The cells of eukaryotic organisms have a DNA content characteristic for each species. When packed in a metaphase chromosome, the DNA is compacted to 10, fold. Most, if not all, of the DNA is present in chromatin, which is a complex of DNA with an equal weight of basic proteins called histones. Differential DNA methylation in high-grade serous ovarian cancer (HGSOC) is associated with tumor behavior Henry D. Reyes, 1, 2, 3 Eric J. Devor, 1, 2 Akshaya Warrier, 1 Andreea M. Newtson, 1, 2 Jordan Mattson, 1 Vincent Wagner, 1 Gabrielle N. Duncan, 2 Kimberly K. Leslie, 1, 2 and Jesus Gonzalez-Bosquet 1, 2Author: Henry D. Reyes, Henry D. Reyes, Henry D. Reyes, Eric J. Devor, Eric J. Devor, Akshaya Warrier, Andre. This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral : Hardcover.